May 2007
Volume 48, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2007
Scleral Permeability of Steroid in Pig and Rabbit
Author Affiliations & Notes
  • Y. Horibe
    Research and Development Division, Santen Pharmaceutical Co Ltd, Ikoma, Japan
  • S. Fujii
    Research and Development Division, Santen Pharmaceutical Co Ltd, Ikoma, Japan
  • K. Yamada
    Research and Development Division,
    Santen Pharmaceutical Co Ltd, Osaka, Japan
  • Y. Nakada
    Research and Development Division,
    Santen Pharmaceutical Co Ltd, Osaka, Japan
  • A. Kimura
    Research and Development Division,
    Santen Pharmaceutical Co Ltd, Osaka, Japan
  • H. Sakai
    Sales and Marketing Division,
    Santen Pharmaceutical Co Ltd, Osaka, Japan
  • K. Kawazu
    Research and Development Division, Santen Pharmaceutical Co Ltd, Ikoma, Japan
  • Footnotes
    Commercial Relationships Y. Horibe, Santen Pharmaceutical Co., Ltd., E; S. Fujii, Santen Pharmaceutical Co., Ltd., E; K. Yamada, Santen Pharmaceutical Co., Ltd., E; Y. Nakada, Santen Pharmaceutical Co., Ltd., E; A. Kimura, Santen Pharmaceutical Co., Ltd., E; H. Sakai, Santen Pharmaceutical Co., Ltd., E; K. Kawazu, Santen Pharmaceutical Co., Ltd., E.
  • Footnotes
    Support None.
Investigative Ophthalmology & Visual Science May 2007, Vol.48, 5795. doi:
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    • Get Citation

      Y. Horibe, S. Fujii, K. Yamada, Y. Nakada, A. Kimura, H. Sakai, K. Kawazu; Scleral Permeability of Steroid in Pig and Rabbit. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5795.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose:: To determine the permeability of sclera to steroid in pig and rabbit.

Methods:: Male domestic pigs and pigmented rabbits were used. All animal experiments were conducted according to the ARVO statement for use of the animals in ophthalmic and vision research. A sustained release formulation was used to deliver steroid across the sclera of animals. After dosing, concentrations of steroid were determined in choroid-retina and dose site (Tenon’s capsule and episclera) at 1 day postdose using a LC/MS/MS method.

Results:: The steroid concentrations of choroid-retina in pigs and rabbits, average of 4-6 eyes were about 600 ng/g and 6,000 ng/g, respectively. The steroid amounts of dose site in pigs and rabbits, average of 4-6 eyes were about 4,000 µg and 3,000 µg, respectively.

Conclusions:: It has been reported that the scleral thickness of pig is very similar to that of human, approximately 0.4-1.0 mm. On the other hand, the scleral thickness of rabbit eye is 0.2 to 0.25 near the equator. This in vivo study suggested that the scleral thickness might affect to the scleral permeability of steroid. References: Invest Ophthalmol Vis Sci., 2002; 43: 2529-2532, Am J Ophthalmol., 1998; 125: 237-241.

Keywords: corticosteroids • sclera • diabetic retinopathy 
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