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A. A. Foulis, S. M. Dudgeon, F. M. Dolan, S. W. Parks, D. Keating; Combining SLO/OCT and Micro-mfERG to Monitor Patients Being Treated for Age-Related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2007;48(13):5991.
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To assess the viability of Multimodal Imaging (MMI) using combined Optical Coherence Tomography (OCT), Scanning Laser Ophthalmoscope (SLO) and micro-multifocal ERG (micro-mfERG) to monitor patients post-treatment.
An Organic Light Emitting Diode display (OLED) was incorporated into an OCT/SLO scanner (OTI, Toronto, Canada) to enable high resolution micro-mfERG recording and OCT/SLO imaging to be carried out simultaneously. Whilst recording the micro-mfERG, OCT scans were performed in both the coronal and the transverse planes at several locations to ensure accurate correlation of structure and function at multiple sites.Six patients undergoing Photodynamic Therapy (PDT) for the wet form of Age-Related Macular Degeneration (ARMD) were tested using MMI. Each patient was tested prior to treatment and subsequently at 2 weeks, 6 weeks and 3 months post-treatment. The patient was asked to fixate on a cross at the centre of the micro-mfERG array and the operator monitored the patient’s fixation using the confocal fundus image.
An accurate correlation of the structural and functional changes following PDT has been made possible using MMI. Thus far the results indicate that the region of the macula affected by functional abnormalities extends beyond the region where structural defects are seen. Furthermore, the spatial resolution of micro-mfERG is higher than that of conventional mfERG therefore allowing subtle changes in function to be detected more easily.
MMI provides the ability to correlate functional and structural information in an objective manner which is beneficial when monitoring the effectiveness of a treatment such as PDT.
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