May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Transconjunctival Needling Revision With 5–Fluorouracil Versus Medical Treatment in Encapsulated Blebs: A 6 Month Prospective Study
Author Affiliations & Notes
  • R. Suzuki
    Ophthalmology, HC–FMUSP, Sao Paulo, Brazil
  • R.M. Vessani
    Ophthalmology, HC–FMUSP, Sao Paulo, Brazil
  • R. Susanna, Jr.
    Ophthalmology, HC–FMUSP, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  R. Suzuki, None; R.M. Vessani, None; R. Susanna, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 18. doi:
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      R. Suzuki, R.M. Vessani, R. Susanna, Jr.; Transconjunctival Needling Revision With 5–Fluorouracil Versus Medical Treatment in Encapsulated Blebs: A 6 Month Prospective Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):18.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the efficacy and safety of transconjuctival needling revision with 5–fluorouracil (TNR) and medical treatment in glaucomatous eye with encapsulated bleb (tenon’s cyst) after trabeculectomy

Methods: : Prospective and consecutive study of glaucomatous eyes submitted to trabeculectomy that developed encapsulated blebs with intra ocular pressure (IOP) ≥ 20mmHg. Eyes were randomized to either TNR or medical treatment. All eyes were followed up for at least 6 months. A maximum of two TNR was allowed in the study. Failure of treatment was defined as intra ocular pressure ≥ 18mmHg.

Results: : 39 eyes were included in the study. 20 eyes were submitted to TNR. 3 eyes required a second needling revision. 19 eyes were treated with medication. There was no significant difference in mean IOP before treatment, sex and race between groups. After 6 months treatment failure was observed in 6 eyes of the group submitted to TNR and in 7 eyes of the group submitted to clinical therapy (p=0.83). Mean IOP in eyes submitted to TNR was 11.8 mmHg and 14.6 mmHg in eyes treated with medication. This difference was significant (p=0.0027). Complication were observed in 2 eyes submitted to TNR (1 eye with grade III flat anterior chamber and coroidal detachment and 1 eye with grade III flat anterior chamber and hyfema).

Conclusions: : Mean intra ocular pressure is lower after TNR comparing with medical treatment after 6 months follow–up. However, in this study no significant difference in treatment failure was observed between the two groups.

Keywords: intraocular pressure • wound healing 
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