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L.A. Oliveira, A.I. Shiguematsu, T. Takata, O.F. Gompertz, L.A. S. M. Junior, L.A. Vieira, L.B. Sousa, M.J. Mannis; Topical Effect of Povidone–iodine Compared With Natamycin in Fungal Keratitis Caused by Fusarium solani in a Rabbit Model. A Pilot Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):296.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the efficacy of topical administration of 0.5% povidone–iodine on experimental Fusarium solani keratitis in rabbits.
Fungal keratitis caused by Fusarium solani was induced in the left eye of 24 New Zealand rabbits. The rabbits were randomly divided into 3 different treatment groups: Gr.I: treated with topical 0.5% povidone–iodine hourly (7am – 11pm) for three days; Gr.II: treated with topical 5% natamycin hourly (7am – 11pm) for three days; and Gr.III: treated with topical salt solution hourly (7am – 11pm) for three days. Rabbits were sacrificed and the corneas were excised, macerated and immersed in 10 ml of BHI. Culture samples were plated daily on Sabouraud’s agar for 7 days. The number of colony–forming units was counted.
Groups I and II showed a greater efficacy than group III comparing the number of rabbits in which there were no growing colonies. However, considering the number of colony–forming units between the 3 groups, there was no statistical significance difference.
Using this methodology of counting colony–forming units, topical 0.5% povidone–iodine showed no benefit in the treatment of experimental fungal keratitis caused by Fusarium solani when compared with topical 5% natamycin.
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