May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Performance and Limitations of Customized Wavefront Aberration–Correcting IOLs
Author Affiliations & Notes
  • P.A. Piers
    Applied, AMO, Groningen, The Netherlands
  • H.A. Weeber
    Applied, AMO, Groningen, The Netherlands
  • Footnotes
    Commercial Relationships  P.A. Piers, Advanced Medical Optics, Inc., E; H.A. Weeber, Advanced Medical Optics, Inc., E.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 320. doi:
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      P.A. Piers, H.A. Weeber; Performance and Limitations of Customized Wavefront Aberration–Correcting IOLs . Invest. Ophthalmol. Vis. Sci. 2006;47(13):320.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the optical performance and limitations of spherical, aspheric, toric and wavefront–customized intraocular lenses (IOLs) in clinically verified eye models.

Methods: : Corneal topography, axial length and keratometry were measured for 46 individual cataract patients included in a clinical trial and used to assemble 46 individual white light eye models. These models were subsequently verified by comparing the average predicted values of modulation transfer function (MTF) and wavefront aberration to average clinical measurements of contrast sensitivity function (CSF) and wavefront aberration measured for pseudophakic patients implanted with spherical and aspheric IOLs. Each eye model was then used to design 2 IOLs that correct astigmatism and higher–order aberrations and to investigate how this correction would affect contrast improvement, subjective tolerance to lens misalignment (tilt, decentration and rotation) and depth of field.

Results: : Correcting individual ocular wavefront aberrations with an IOL results in average improvements of 200% for the area under the radial MTF curve from 1.5 to 18 c/deg. The customized lenses can be, on average, decentered 0.8 mm, tilted 10 degrees and rotated 15 degrees before their polychromatic MTF at 8 c/deg is less than that of standard IOLs (spherical and aspheric). Customized correction of wavefront aberration results in a narrower depth of field, but for plus and minus 0.5D of defocus, the performance of the customized lenses is better than or equal to that of standard IOLs.

Conclusions: : Customized IOLs show the potential to improve contrast vision.

Keywords: intraocular lens • optical properties • topography 
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