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Y. Terada, I. Takasu, Y. Morizane, R. Takabatake, K. Okamoto, M. Hosogi, H. Ohtsuki; Verteporfin Photodynamic Therapy Affects Physiological Circulation of Collateral Choroid in Age–Related Macular Degeneration and Polypoidal Choroidal Vasculopathy (In Japan) . Invest. Ophthalmol. Vis. Sci. 2006;47(13):375.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effect of a single session verteporfin photodynamic therapy (PDT) on perfusion of choroidal neovascularization (CNV) and collateral physiological choroid in Japanese patients.
Thirty–eight eyes in 35 Japanese patients with subfoveal CNV were treated with verteporfin PDT. Indocyanine green angiography (IA), using a confocal laser scanning system, and fluorescein angiography (FA) were performed before and 1, 4 and 12 weeks after the treatment.
Twenty–four eyes were diagnosed as age–related macular degeneration (AMD) and 14 eyes were polypoidal choroidal vasculopathy. Twelve weeks after PDT, CNV lesions were significantly reduced especially in PCV (92.9%). In AMD patients, 48% of CNV lesions showed reduction in perfusion and 50% of CNV lesions continuously being perfused. FA showed hypofluorescence especially in early–phase in the entire photosensitized area 1 week after PDT. The fluorescence gradually increased in time and the treatment spots were not distinguishable in most cases 4 weeks after PDT on FA. One the other hand, IA showed persistent hypofluorescecnce of the same area throughout the late phase in 76.3% even 4 weeks after PDT. The fluorescence gradually increased in time, however, 57.9 % of treated eyes still showed collateral hypofluorescence 12 weeks after PDT.
PDT was effective in Japanese patients with subfoveal CNV. IA revealed persistent hypofluorescence in collateral physiological choroid that was not detected in FA.
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