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X. Zhong, G. Tan, J. Ge; Long–Term Changes in Ocular Anterior Segment After Implantation of Phakic Anterior Chamber Intraocular Lens in Rhesus Monkeys . Invest. Ophthalmol. Vis. Sci. 2006;47(13):607.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the influence of phakic intraocular lens on anterior segment in rhesus monkeys and to evaluate the safety of implantation of phakic anterior chamber intraocular lens.
Phakic anterior chamber intraocular lens was implanted into one eye of the seven healthy monkeys, while the other eye was used as the control eyes. The changes of anterior segment and refractive status were assessed periodically by Anterior segment analysis system, Confocal Microscope,Orbscan II system, retinoscopy, A–scan ultrasonography, and histopathology examination.
Phakic anterior chamber intraocular lenses were successfully implanted in all seven monkeys, and the average distance from the corneal endothelium to the anterior surface of the intraocular lens was 2454µm(2454±170µm). And the average distance from the posterior surface of the intraocular lens to anterior capsule of the crystalline lens was 410 µm(410±114µm). Histopathology showed that TM,the anterior chamber angle,iris and ciliary body were structurally normal, with few lymphocytes infiltrated both in the experimental eyes and control eyes. Corneal endothelium cells of the experimental eyes in preoperative examination and 36 months after operation were statistically different (2875±103 cells/mm² vs 2351±451 cells/mm², t=5.42, p=0.0002). There was no statistical difference in keratocytes (p>0.05).
The implantation of phakic anterior chamber intraocular lens had little influence on cornea, anterior chamber, anterior chamber angle, and crystalline lens and caused slight non–specificity inflammatory reaction. However, corneal endothelium cells decreased. The implantation of phakic anterior chamber intraocular lens had little influence on cornea, anterior chamber, anterior chamber angle, and crystalline lens and caused slight non–specificity inflammatory reaction. However, corneal endothelium cells decreased. (This work was supported by a grant from The Natural Science Foundation of Guangdong Province (04105323), Fok Ying Tung education foundation (91043), and The Science Foundation of Guangdong Province(2003C32707))
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