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J. Matsumoto, Y. Chu, M. Sell; Clinical Evaluation of Viscous Tetracaine HCL 0.5% Ophthalmic Solution . Invest. Ophthalmol. Vis. Sci. 2006;47(13):68.
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To evaluate the effects of topical application of viscous tetracaine HCL 0.5% (TetraViscTM) ophthalmic solution on central corneal thickness.
Single–center, open label study of 20 healthy eyes of 10 patients. The right eye served as the control and received non–preserved carboxymethycellulose sodium 0.5%. Baseline measurements of best–corrected distance visual acuity and Orbscan® analysis were performed on both eyes. Non–preserved carboxymethycellulose sodium was instilled in the right eye of each patient and the left eye received one drop of viscous tetracaine HCL 0.5% (TetraViscTM). After 5 minutes, best–corrected visual acuity and Orbscan® analysis were repeated on both eyes.
Average overall central corneal thickness was increased to a greater degree in the eyes instilled with carboxymethycellulose sodium. The mean central corneal thickness change was increased by 11.1 microns with carboxymethycellulose sodium and 9.2 microns with tetracaine HCL 0.5% (TetraViscTM). There were no significant changes in visual acuities before or after instillation of carboxymethycellulose sodium or tetracaine HCL.
The effects on the central corneal thickness after application of viscous tetracaine HCL 0.5% (TetraViscTM) are less than the non–preserved carboxymethycellulose sodium 0.5%.
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