May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Structure–Function Relationships in Glaucoma: A Comparison of Different Functional Tests
Author Affiliations & Notes
  • C.A. Johnson
    Ophthal–Discoveries in Sight, Devers Eye Institute, Portland, OR
  • S.K. Gardiner
    Ophthal–Discoveries in Sight, Devers Eye Institute, Portland, OR
  • G.A. Cioffi
    Ophthal–Discoveries in Sight, Devers Eye Institute, Portland, OR
  • Footnotes
    Commercial Relationships  C.A. Johnson, Welch Allyn, F; Welch Allyn, C; Welch Allyn, R; S.K. Gardiner, None; G.A. Cioffi, None.
  • Footnotes
    Support  NIH Grant EY03424
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1123. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      C.A. Johnson, S.K. Gardiner, G.A. Cioffi; Structure–Function Relationships in Glaucoma: A Comparison of Different Functional Tests . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1123.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Glaucoma is diagnosed on the basis of a combination of optic nerve structural features, functional tests, and additional clinical information including past medical history. However, the spatial relationship between structure (optic nerve head [ONH] properties) and function (visual fields) is not well defined. This study investigates whether that relationship is dependant on the particular functional test used.

Methods: : In a previous study (Gardiner et al 2005, IOVS 46:3712–7) normalized rim area measurements using the Heidelberg Retina Tomograph (HRT) were compared to perimetric sensitivities measured using white–on–white Standard Automated Perimetry (SAP), in order to derive a map relating regions of the ONH to SAP test locations. This study uses the same analysis technique for Short Wavelength Automated Perimetry (SWAP) and Frequency Doubling Technology perimetry (FDT, Humphrey Matrix), using a 24–2 test pattern in each. 165 eyes of 165 subjects with early glaucoma or glaucomatous optic neuropathy were included in the study, with all four tests being carried out within one month.

Results: : For SAP and FDT, 37 of the 52 non–blind spot locations exhibited a correlation >0.25 with the normalized rim area of at least one sector of the ONH, and 35 did so for SWAP. The best perimetry location – ONH sector correlations were 0.486, 0.450 and 0.417 for SAP, SWAP and FDT respectively.

Conclusions: : The topographical map appeared similar for all three functional tests. The graphical representation produced using SWAP was less clear than those using SAP or FDT, which may be indicative of increased variability. Correlations in the locations near fixation were noticeably poorer for FDT than for SAP or SWAP, which may be caused by the lower proportion of magnocellular mechanisms around the fovea compared with the periphery.

Keywords: visual fields • optic disc • perimetry 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×