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A.E. Fletcher, I. Young, U. Chakravarthy, P. deJong, M. Rahu, J. Seland, G. Soubrane, L. Tomazzoli, F. Topouzis, J. Vioque; Omega Fatty Acids and Age–Related Macular Degeneration in the Eureye Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1132.
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To invesigate the association between omega fatty acids and age–related macular degeneration (AMD)
We conducted a nested case–control study in the 7 country population–based EUREYE study. Of 158 cases with AMD, 149 (46 geographic atrophy, 103 neovascular) had stored blood samples. Cases were matched by country, sex and age (frequency matched within 1 year)with controls who had no signs of early ARM or AMD. Bloods were analysed by capillary gas–liquid chromatography for omega fatty acids: linoleic (LA), alpha linolenic (ALA), eicosapentaenoic (EPA), docosahexanoic(DHA). Statistical analysis was by logistic regression adjusted for potential counfounders (smoking, myocardial infarction, diabetes, serum antioxidants).
ALA was signficantly associated with AMD in both univariate and adjusted analyses with OR for the highest versus lowest tertile of 0.25 (0.11, 0.52), p = 0.0001. Increasing quartiles of LA were associated with decreasing odds of AMD, eg. OR for highest versus lowest quartile of 0.45 (0.23, 0.89) p = 0.02. DHA showed a reduced association for highest versus lowest quartile but was not signfiicant, OR 0.55 (0.27, 1.09) p = 0.09. EPA was not associated with AMD.
In contrast to studies based only on dietary analyses, our results based on blood analysis showed strong inverse associations with higher blood levels of LA and ALA.
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