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D. Borja, A. Rosen, R. Augusteyn, F. Manns, J.–M. Parel; Equivalent Refractive Index of Postmortem Cynomolgus Monkey Crystalline Lenses . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1209.
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© ARVO (1962-2015); The Authors (2016-present)
To calculate the equivalent refractive index of cynomolgus monkey crystalline lenses from optical power, surface curvature, and sagittal thickness measurements.
Measurements were performed on 14 healthy or diabetic isolated cynomolgus postmortem monkey crystalline lenses within 24 hours of euthanasia (PMT = 17±16.4 hours) with an average age of 5±2 years. The lenses were extracted from the donated whole globes and immersed in BSS. The optical power was measured with a modified lensmeter (Denham et al, ARVO 2004). The sagittal thickness was obtained from 20X magnified undistorted sagittal view shadowphotograph images (Rosen et al, Exper Eye Res, In Press). The radii of curvature of the anterior and posterior surfaces of the lens were obtained by fitting conic functions to the anterior and posterior edges of the shadowgraph images and using the value of the apex radius. The central equivalent refractive index was calculated using the lens maker formula.
The average anterior and posterior radii were found to be 3.59±0.44 and –3.60±0.50mm respectively. The average sagittal thickness was found to be 4.04±0.20mm. The average optical power measured at 587nm and at a radius of 2.12mm was found to be 40.06D±4.43. From these measured values the equivalent refractive index was found to be 1.40±0.01.
The lens equivalent refractive index (n=1.40) of the isolated cynomolgus monkeys lens (i.e. accommodated) is comparable but slightly lower than published values for the in vivo accommodated human lens (1.44<n<1.41, Dubbelman 2001 & 2005)
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