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P. Ferreira, G. Lima, F. Ramalho, A. Figueiredo; Influence of Prednisolone Acetate 1% and Ketorolac 0,5% Eyedrops in Endothelial Cell Loss After Cataract Surgery . Invest. Ophthalmol. Vis. Sci. 2006;47(13):680.
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Phacoemulsification has become a routine surgery with low complications rate; hence, the functional outcome is more conditioned by operative trauma. The aim of this study is to compare the influence of prednisolone acetate 1% eye drops and ketorolac 0,5% eye drops in order to prevent corneal endothelial damage after surgery.
Two hundred patients with senile cataracts grade 1 (soft nucleus) were included. Exclusion criteria were history of corneal disease, ocular trauma and inflammation. All surgeries were performed by the same surgeon with clear corneal incision and standard technique. Endothelial densities of the cornea were measured with specular microscopy before and three months after surgery. Patients were divided in two groups (hundred patients each group) using predinisolone acetate 1% eyedrops quid (group 1) and ketorolac 0,5% eye drops quid (group 2) starting 24h after surgery for two weeks in both groups.
The initial preoperative mean cell count for the entire sample was 2434 An average 7,24% (5,41% to 10,21%) reduction in cell count was recorded by 3 months postoperatively in group 1 and 12,82% (6,01% to 15,03%) in group 2.
Our data suggests that prednisolone acetate 1% eye drops is more effective than ketorolac 0,5% in order to avoid endothelial cell loss after cataract surgery.
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