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R.E. Evans, F.A. Bucci, Jr.; A Comparison of Postoperative Inflammation (Flare) Following Routine Phacoemulsification When Using Ketorolac 0.4% vs. Nepafenac 0.1% . Invest. Ophthalmol. Vis. Sci. 2006;47(13):684.
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To compare the amount of postoperative inflammation (flare) in patients receiving ketorolac 0.4% vs. nepafenac 0.1% pre and postoperatively with routine phacoemulsification.
38 phaco patients were randomized to receive either ketorolac 0.4 % or nepafenac 0.1% 4x /day for 2 days preop and every 10 minutes x 4 in the hour prior to surgery. After the post op day 1 visit all patients received prednisilone acetate 1.0% 4x/day in addition to either ketorolac 0.4% or nepafenac 0.1% 4x/day. Flare (Kowa FM–500) was evaluated at 1 day (prior to receiving any steroid), 1 week, and 2 weeks postoperatively. Patients requiring pupilloplasty after randomization and those unable to complete all follow up visits were excluded from analysis. Intraocular pressure was also evaluated at all follow up visits.
One patient in the nepafenac group and two patients in the ketorolac group required pupilloplasty. One patient in the nepafenac group and two patients in the ketorolac group did not complete all follow up visits. The mean flare levels in the ketorolac group (n = 15) were at 1 day (22.9 ± 6.1), 1 week (17.6 ± 5.7), and 2 weeks (13.9 ± 6.2). The mean flare levels in the nepafenac group (n = 17) were at 1 day (19.6 ± 7.2), 1 week (17.6 ± 5.7), and 2 weeks (13.9 ± 6.2). No significant difference in inflammation as measured by flare was observed at any follow up visit when comparing ketorolac 0.4% to nepafenac 0.1%. No significant differences in IOP were observed.
There were no significant differences in postoperative aqueous inflammation (flare) in patients using pre and postoperative ketorolac 0.4% vs. nepafenac 0.1% following routine phacoemulsification.
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