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Y. Liu, X. Gu, L. Zhang, X. Ye, A.A. Sadun; Ice Test – Assessing This as a Tool for the Diagnosis of Myasthenia Gravis . Invest. Ophthalmol. Vis. Sci. 2006;47(13):786.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effects of Ice test on the patients with ptosis by various causes, to reveal the sensitivity and specificity of the ice test for the diagnosis of myasthenia gravis(MG) by randomized, noninterventional trial.
32 subjects with ptosis from newly diagnosed MG and 33 subjects with nonmyasthenic ptosis were examined by both the ice test and rest test. Two masked observers were asked to evaluate the improvement in eyelid elevation.
both the ice test and rest test did showed marked improvement in the myasthenic ptosis, but did not show amelioration on the patients with nonmyasthenic ptosis. Hence, there was 100% specificity obtained in both tests. However, the ice test was more likely to improve ptosis than rest test alone in MG subjects, thus demonstrating a higher sensitivity (78%).
The ice test is a simple, short, specific, sensitive and remarkably specific test for the diagnosis of myasthenic ptosis.
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