Purchase this article with an account.
H.G. Yu, S.J. Kim, S. Kim, J.–M. Seo, K.S. Park, Y. Kim; Differential Expression of Vitreous Proteins in Proliferative Diabetic Retinopathy . Invest. Ophthalmol. Vis. Sci. 2006;47(13):961.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To identify vitreous proteins which were differentially expressed in patients suffering from proliferative diabetic retinopathy with active neovascularization.
The vitreous samples of 15 active proliferative diabetic retinopathy patients were analyzed by two–dimensional gel electrophoresis and mass spectrometry, and the results were compared with those from age–matched patients with macular hole.
25 protein spots were identified in the two–dimensional gel electrophoresis gels. Eight proteins in the 25 spots were expressed significantly differently between the macular hole and proliferative diabetic retinopathy patients (p value < 0.05). Five proteins were up–regulated in the proliferative diabetic retinopathy patients, and three were down–regulated (p value < 0.05).
We constructed vitreous protein profiles for the proliferative diabetic retinopathy patients, and identified eight candidate proteins believed to be involved in the pathogenesis of proliferative diabetic retinopathy.
This PDF is available to Subscribers Only