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E. Brasnu, T. Bourcier, C. Chaumeil, B. Dupas, T. Rodallec, L. Laroche, C. Baudouin; In vivo Confocal Microscopy: Findings of Fusarium Keratitis . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1340.
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© ARVO (1962-2015); The Authors (2016-present)
Fusarium Keratitis (FK) is a potentially blinding progressive disease that is frequently diagnosed at a late stage. Like any infectious keratitis, it benefits from early detection and treatment. Heidelberg Retina Tomograph II (HRTII) (Heidelberg engineering, Dossenheim, Germany) examination was performed with the cornea module in two patients with FK to provide images detailing characteristic findings of the disease.
A 55–year–old man and a 68–year–old woman presented with clinical signs and symptoms of FK. HRTII confocal microscopy with the cornea module was performed. Pictures were taken from all corneal structures of the central and peripheral cornea and compared to those of healthy subjects. Both patients underwent laboratory investigations.
HRTII examination with the cornea module revealed numerous high–contrast lines 200–300 µm in length and 3–5 µm in width with branches at 90° angles in the anterior stroma of both patients, resembling fusarium hyphae. Dendritiform and round–shaped inflammatory cells were also present at the epithelial level and in the area of stromal infiltrates. Epithelial and stromal disorganization was observed, with keratocyte activation aspects. Confirmation of FK was obtained by cytological examination of corneal smears which revealed the presence of numerous fusarium.
HRTII cornea module provides non–invasive, high–contrast, in vivo images of the cornea. It can be helpful in the diagnosis of FK by identifying fusarium hyphae–like structures in the cornea.
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