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M.G. Aly, H. Yamamoto, E.M. Espana, M.A. Orozco, M. Aguilar, E. Arrieta, L. Pinchuk, J. Martin, W. Smiddy, J.–M. Parel; A Novel Material for Scleral Buckle Procedures – An Experimental Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1487.
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To evaluate in normal NZW rabbits the surgical and clinical outcomes of scleral buckles made of poly(styrene–b–isobutylene–b–styrene)(SIBS). SIBS is a novel polymer used in paclitaxel eluting stents (TAXUSTM, Boston Scientific).
In 6 eyes, a segmental circumferential buckle was implanted under an encircling band that was secured by a sleeve, all made of SIBS (InnFocus LLC, Miami, FL). A control group of 5 eyes underwent implantation of identically shaped implants made of PDMS (Labtician Inc, Canada; Silicone Band #240, Sleeve #3083, and Buckle #219). Slit lamp evaluation was done at POD 3, 14, 21, 28, 56, 120, 180. Fundus evaluation under anesthesia was done immediately after surgery and together with slit lamp evaluation and ophthalmoscopy at POD 7, 42, 90, 180, and then monthly thereafter until 9 months.
Average surgery time was 84+/–9 min. Intraoperative retinal perforation by suture needle occurred in 1 SIBS and in 4 PDMS eyes resulting in a limited hemorrhage in 2 of the PDMS eyes which subsided intraoperatively. No retinal detachment, vitreous opacities, panophthalmitis or extrusion were observed in any of the operated eyes. During the first 7 weeks, the average conjunctival hyperemia was 0.2 for SIBS and 1.15 for PDMS; at 6 month, it was 0 for SIBS and 0.3 for PDMS; while at 9 months it was 0 for both groups. One of the SIBS implanted eyes showed anterior migration of the sleeve at 6 months due to slippage of 1 of 4 securing sutures. PDMS implants showed surface conjunctival neovessels. None of the SIBS implanted eyes showed any inflammatory reaction or neovascularization suggesting good biocompatibility. Buckling effect was slightly higher among the SIBS implanted eyes but not statistically significant.
SIBS scleral buckle implants were found to be biocompatible in the rabbit model. As SIBS allows for controlled drug release, it could become useful in the treatment of complicated retinal detachment and recurrent PVR.
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