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Y. Yucel, A. Darabie, S. Wang, P.L. Kaufman, N. Gupta; Glutamate NMDA Receptor 1 Subunit Expression Is Increased in the Lateral Geniculate Nucleus of Experimental Glaucoma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1555.
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© ARVO (1962-2015); The Authors (2016-present)
To determine whether the NMDA receptor implicated in glutamate excitotoxicity, is over–expressed in the lateral geniculate nucleus (LGN) of experimental glaucoma.
Eight adult cynomolgus monkeys with unilateral experimental glaucoma for up to 11 months duration, and 3 normal monkeys were studied. LGN layers were examined following immunocytochemical staining with antibody to NMDA receptor 1 subunit (NMDA R1).
In the normal LGN, NMDA R1 immunoreactivity was present, and evenly distributed across layers 1 to 6. In glaucomatous LGN, NMDA R1 was also present in all 6 layers, but NMDA R1 expression was increased in layers connected to the glaucomatous eye compared with those connected to the non–glaucomatous eye.
Glutamate NMDA R1 receptor is increased in LGN layers connected to glaucomatous eyes in monkeys. This finding suggests that glutamate is involved in glaucomatous CNS degeneration, and may be relevant to treatment strategies in glaucoma.
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