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M.I. Chase, I. Glybina, F. Zwas, G.W. Abrams; Age and Myopia–Related Changes in Multifocal Electroretinography (Mferg) Recorded With Lcd Monitor–Provided System in Normal Subjects . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1659.
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© ARVO (1962-2015); The Authors (2016-present)
To determine normal values for N1 and P1 components of mfERG responses recorded with LCD monitor–based multifocal system in normal subjects of different age groups with and without moderate–to–high myopia.
The study was performed in 52 volunteers divided into four groups. Group A included 16 emmetropes 18–45 y/o; group B – 17 emmetropes 45–75 y/o; group C – 13 myopes 18–45y/o; group D – 6 myopes 45–75y/o. For the recording, VERISTM multifocal system (San Mateo, CA) was used and 103–hexagonal element stimulus was employed. Latencies and amplitudes of N1 and P1 components were evaluated. For the statistical analysis one way ANOVA with concomitant paired t–test were performed.
As compared with the group A, at the 0º eccentricity, mean values for the N1 amplitude were reduced by 2.26% in group B, by 9.15% in group C, and by 12.9% in group D (p<0.05); mean values for the P1 amplitude were reduced by 10.65% in group B (p<0.05), by 14.1% in group C (p<0.05), and by 40.8% in group D (p<0.05). At the eccentricities from 5º to 25º, mean values for the N1 amplitude were reduced by 5.22±3.7% in group B, by 11.54±7% in group C (p<0.05), and by 31.85±5.15% in group D (p<0.01); mean values for the P amplitude were reduced by 0.9–1% in group B, by 19.25±3.3% in group C (p<0.05), and by 22.5±4.5% in group D (p<0.05). The table shows averages (nV) and standard deviations for the P1 amplitude in groups A–D at different eccentricities:
The N1 and P1 latencies within the central 10º were not significantly different between the groups; however, at the eccentricities from 15º to 25º there was a significant delay of both N1 and P1 in group D as compared with other groups.
Our findings indicate age–related and myopia–related depression of cone function in the posterior pole of the eye. The data can be used as a normative database in the evaluation of retinal function by means of LCD monitor–provided multifocal system in myopic and non–myopic patients of different age groups.
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