May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Antibiotics Delivery IOL
Author Affiliations & Notes
  • Y. Tsuchiya
    Toho University, Tokyo, Japan
    The First Department of Ophthalmology,
  • S. Kobayakawa
    Toho University, Tokyo, Japan
    The First Department of Ophthalmology,
  • Y. Okajima
    Toho University, Tokyo, Japan
    The First Department of Ophthalmology,
  • A. Tsuji
    Toho University, Tokyo, Japan
    Department of Infection control and prevention,
  • T. Tochikubo
    Toho University, Tokyo, Japan
    The First Department of Ophthalmology,
  • Footnotes
    Commercial Relationships  Y. Tsuchiya, None; S. Kobayakawa, None; Y. Okajima, None; A. Tsuji, None; T. Tochikubo, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 1900. doi:
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    • Get Citation

      Y. Tsuchiya, S. Kobayakawa, Y. Okajima, A. Tsuji, T. Tochikubo; Antibiotics Delivery IOL . Invest. Ophthalmol. Vis. Sci. 2006;47(13):1900.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the ability of hydrophilic acrylic intraocular lens (IOL), MeridianTM (Baush&Lomb), to serve as an antibiotics delivery system into the eye.

Methods: : Levofloxacin (LVFX, 0.5% and 1.5%) and Gatifloxacin (GFLX, 0.3%) were used. 1. Meridian IOL were presoaked for 24 hours in LVFX (0.5% and 1.5%), released concentrations from IOL were detected using by HPLC. 2. Presoaked for 24 hours in 0.5% LVFX and 0.3% GFLX, inhibition zone diameter for Enterococcus faecalis (two strains from clinical isolates) and for Staphylococcus epidermidis (ATCC12228 and 35984) were measured. 3. After presoaked for 24 hours in 0.5%LVFX, E. faecalis (one of two strain) and S. epidermidis (ATCC 35984) were used to seed biofilm on IOL (106∼107 CFU/ml). Bacterial population within biofilms was examined through 72 hours incubation.

Results: : 1. High LVFX concentrations (1.14∼1.83 mcg/ml) were found until 48 hours. After 72 hours, those concentrations decreased (0.33 mcg/ml). 2. Inhibition zones for all tested strains were found. Inhibition zone diameter with GFLX showed bigger than that with LVFX in E.faecalis (p<0.05). 3. There were no bacteria on presoaked IOL in E.faecalis through 72 hours. There were no bacteria on presoaked IOL in S.epidermidis (ATCC 35984) initial 24 hours. However, after 48 and 72 hours incubation, numbers of adherent bacteria (S.epidermidis, ATCC35984) were 103∼104 CFU/ml.

Conclusions: : Meridian IOL that presoaked in antibiotics inhibited the bacterial proliferation within 24 hours. Those treated IOL may prevent to develop the endophthalmitis.

Keywords: endophthalmitis • intraocular lens • antibiotics/antifungals/antiparasitics 
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