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H. Kagokawa, A. Takahashi, E. Sato, J. Takahashi, A. Takamiya, K. Sogawa, Y. Minami, S. Ishiko, A. Yoshida; Change in Choroidal Blood Flow After Photodynamic Therapy in Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2108.
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© ARVO (1962-2015); The Authors (2016-present)
We reported previously that pulsatile ocular blood flow (POBF), a parameter for evaluating choroidal blood flow (CBF), is lower in patients with exudative age–related macular degeneration (AMD) than in normal subjects. The aim of this study was to evaluate the changes in CBF after photodynamic therapy (PDT) in patients with exudative AMD.
Nineteen patients with exudative AMD (19 eyes; 12 men, 7 women; age range, 58–84 years) who underwent PDT were included in the study. PDT with verteporfin (Visudyne®) was administered. We evaluated the POBF using Langham OBF computerized tonometry before and 10 days and 3 months after the administration of PDT.
The POBF (median, 665.1µl/min) increased significantly 10 days after administration of PDT compared to that before administration of PDT (median, 598.3µl/min) (p<0.05). However, that increased POBF tended to decrease 3 months after PDT administration. There was no significant difference between the POBF 3 months after administration of PDT (median, 639.6µl/min) and the POBF before administration of PDT.
The results of this study suggest that PDT may affect the CBF in the early phase of PDT.
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