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M. Gupta, A. Shakoor, N. Blair, M. Shahidi; Quantative Measurement of Retinal Thickness and Pigment Epithelial Detachment in Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2135.
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To investigate the relationship between thickness of the retinal tissue overlying pigment epithelial detachment (PED) and the PED elevation in patients with age–related macular degeneration (AMD).
Ten patients, 6 male and 4 female with an average age of 76 + 7 yrs (mean + SD) with clinical diagnosis of AMD and pigment epithelial detachment were imaged using optical coherence tomography (OCT). OCT images from vertical or horizontal scans were used to manually measure the retinal thickness and PED elevation with the OCT software. Retinal thickness was measured by the depth separation between retinal pigment epithelium and inner limiting membrane. PED elevation was measured by the depth separation between the detached retinal pigment epithelium and undetached retinal pigment epithelium in an adjacent area. For each eye, 5 measurements were obtained within 300 microns of fixation point and averaged. Linear regression analysis was performed to relate retinal thickness, PED elevation and visual acuity.
The mean retinal thickness was 280 + 93 microns (N = 10) ranging between 126 and 438 microns. The PED elevation measured in 10 patients ranged between 104 and 296 microns with an average of 179 + 70 microns. The mean visual acuity in 8 patients was 0.7 + 0.4 (log MAR units) and 2 patients had visual acuity of counting fingers. A marginally significant linear correlation was found between pigment epithelial detachment elevation and the overlying retinal thickness (R = 0.6; P = 0.05; N = 10). No significant correlation was observed between retinal thickness and visual acuity (R = 0.05; P = 0.9; N = 8).
These results suggest an association between retinal thickness and elevation of the detached retinal pigment epithelium
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