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T.I. Metelitsina, J.E. Grunwald, J.C. DuPont, G.–S. Ying, J. Alexander, R.E. Martin, K.M. Matias; Association Between Age–Related Macular Degeneration (AMD) Fundus Features and Foveolar Choroidal Circulation . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2169.
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To investigate the relationship between typical funduscopic features of AMD and foveolar choroidal circulation in patients with AMD.
Measurements of relative choroidal blood velocity (ChBVel), volume (ChBVol) and flow (ChBFlow) in the center of the fovea were obtained in 181 study eyes of 134 patients with AMD using laser Doppler flowmeter (Oculix instrument). All study eyes had visual acuity of 20/40 or better and no signs of choroidal neovascularization (CNV). Presence of RPE hypertrophy and RPE depigmentation, drusen size and number, % area covered by drusen were assessed from color fundus photographs in a masked fashion by trained graders. Multivariate linear regression analysis was carried out with adjustments for significant covariates (age, intraocular pressure and perfusion pressure for ChBVel; age and intraocular pressure for ChBVol; age for ChBFlow). The correlation between paired eyes from the same subject was adjusted by using the generalized estimating equations (GEE). Results of choroidal circulatory parameters are shown in arbitrary units (AU).
Clinical AMD features related with poor visual prognosis are generally associated with decreased ChBFlow. As shown in the above table the changes in flow are mostly due to changes in ChBVol.
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