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E. Rechtman, A. Harris, T.A. Ciulla, R.P. Danis, B. Siesky, E. Brizendine, D. Sines, C.W. Yung, O. Geyer, H.J. Garzozi; The Relationship Between Retrobulbar and Choroidal Hemodynamics in Non–Neovascular Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2170.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the relationship between retrobulbar and choroidal hemodynamics in non–neovascular age–related macular degeneration (AMD)
In a prospective study, 13 non–neovascular AMD patients were assessed by both color Doppler imaging (CDI) and scanning laser ophthalmoscope indocyanine green (SLO ICG) angiography. CDI was used to measure peak–systolic and end–diastolic velocity (PSV and EDV) (from which the resistance index (RI) was calculated) in the ophthalmic, central retinal, and posterior ciliary arteries. SLO ICG angiograms were analyzed by area dilution analysis (ADA), which yields fluorescence intensity parameters within perifoveal and temporal peripapillary regions. All CDI parameters were correlated with all SLO ICG ADA measurements. In addition, CDI and SLO ICG parameters were correlated with visual acuity and axial length. Pearson correlation was used to compare CDI parameters (PSV, EDV, RI) with ICG measures (duration, 10% and 63% filling times) and A–scan and visual acuity with CDI and ICG parameters. P values < 0.05 were considered statistically significant.
Significant positive correlations were found between the posterior ciliary arteries RI and SLO ICG ADA fluorescence duration (peripapillary: p < 0.05, r = 0.78; perifoveal: p < 0.05, r = 0.72). There were moderate correlations between the ophthalmic artery CDI RI and SLO ICG 63% filling time parameters (peripapillary: NS; perifoveal: p < 0.05, r = 0.57). No correlations were found between central retinal artery CDI RI and SLO ICG parameters. Also, CDI and SLO ICG parameters did not correlate with the patients’ visual acuity or with the axial length.
SLO ICG ADA duration correlates with posterior ciliary arteries RI and may help in AMD, as well as in other ocular disease, vascular assessment.
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