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Y. Feng, K. Dumbleton, N. Keir, C.A. Woods, L.W. Jones, T.L. Simpson, D. Fonn; The Influence of a Guar–Based Lubricant Eye Drop on Ocular Discomfort in Symptomatic Hydrogel Contact Lens Wearers . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2381.
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To compare the effects of a hydroxypropyl guar–based lubricant eye drop (Systane®, Alcon, "test") with the effects of a 0.9% saline drop (control) on contact lens–related ocular dryness in symptomatic hydrogel contact lens wearers.
This was a one–month, prospective, daily wear, double–masked clinical trial, with a randomized parallel design. Seventy–nine contact lens wearers reporting symptoms of ocular dryness or discomfort were recruited and randomly separated into treatment and control groups. Drops were instilled twice daily, pre– and post–contact lens wear. The frequency of habitual rewetting drop use was reported at baseline and subjective evaluation of comfort, dryness and comfortable lens wear time were reported using a questionnaire at the baseline visit and every three to four days during the study. Bulbar conjunctival redness was measured at the baseline, two–week and four–week visits using a Spectrascan650 photometer.
The overall effect of the test product on the lens–wearing experience was superior to the effect of the control drops. Use of the test drop increased comfortable lens wear time after 10 days and continued to do so for the remainder of the study period (p<0.05). After 10 days, 53% of the test participants reported an increased comfortable lens wear time of >1 hour (vs. 36% for the control) and 35% reported >2 hours increase (vs. 26% for the control). The mean comfortable lens wear time before and after treatment were 7.9±3.0 (mean±SD) and 9.5±2.9 hours for the test group, compared with 7.4±3.2 and 8.1±3.2 hours for the control group. Subjects using the test drop also reported that their lenses were more comfortable on insertion, more comfortable and less dry at the end of the day, and that they were able to wear their lenses for a longer period of time (all p<0.05). There were no significant changes in ocular redness for participants in either group across the period of the study (p>0.05).
This study indicates that the use of a lubricant eye drop containing hydroxypropyl guar (Systane®) twice daily (pre– and post–contact lens wear) increases comfortable lens wear time in symptomatic contact lens wearers, compared with the use of a saline control drop.
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