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T.C. Vaz, S. Groemminger, L. Stiffler, M. Robboy; Water Retention in Dry Eye Subjects of Soft Contact Lenses Treated With Two Different Multi–Purpose Solutions . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2402.
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A clinical evaluation was undertaken to assess whether changes in water content and contact wetting angle can be demonstrated in dry eye subjects immediately after wearing Acuvue® 2 lenses soaked in Bausch & Lomb ReNu® with MoistureLocTM, when compared to Acuvue® 2 lenses soaked in Alcon Opti–Free® Express®.
20 dry eye subjects, all habitual soft spherical contact lens wearers with a computer–based visual analog dryness score of 70 or less on a 100–point scale, were each enrolled in a clinical evaluation. Test and control solution lenses were pre–treated in ReNu® with MoistureLocTM and in Alcon Opti–Free® Express respectively, in pre–treated lens cases. Each subject wore a test ReNu with MoistureLoc/Acuvue® 2 lens and an Alcon Opti–Free® Express control solution/Acuvue® 2 lens on contralateral eyes for approximately 4 hours. After the 4 hours, lenses were removed from the eye, and immediately weighed on an analytical balance. Contact wetting angle was then measured using a goniometer. Lenses were placed into a vacuum chamber overnight under pressure at ambient temperature and subsequently re–weighed.
The ReNu® with MoistureLocTM soaked test lenses exhibited statistically significant less mean relative percent total water loss compared to the Alcon Opti–Free® Express® soaked control lenses. The test lenses lost 11.2 percent of their total water content, while the control lenses lost 13.2 percent of their total water content. The test lenses exhibited a statistically equivalent mean contact wetting angle compared to the control lenses. The ReNu® with MoistureLocTM soaked test lenses had a contact wetting angle of 21 degrees, while the Alcon Opti–Free® Express® soaked control lenses also had a contact wetting angle of 21 degrees.
The results of this study indicate that ReNu® with MoistureLocTM exhibits the capacity to decrease the level of lost water while maintaining a similar contact wetting angle in lenses worn by contact lens dry eye subjects compared to Alcon Opti–Free® Express®.
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