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S. Kobayakawa, Y. Katayama, H. Yanagawa, H. Watanabe, T. Tochikubo; The Relationship Between the Adhesion Characteristics of Acrylic IOLs Materials and Posterior Capsule Opacification . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2544.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the relationship between the adhesion characteristics of several acrylic intraocular lenses (IOLs) materials and posterior capsule opacification (PCO).
Three similar shaped hydrophobic acrylic IOLs were used. 1. Human lens epithelial cells (HLEC, SRA 01/04) were grown on each IOL. Cellular migration and proliferation assays were performed using by collagen inserts (Biocoat, BD Bioscience, U.S.A). After 96 hours incubation, the membrane for collagen inserts were stained and analysed using by Scion image. 2. Three kinds of IOLs were implanted to Japanese albino rabbits. Three weeks later, each sample were enucleated, and analyzed PCO area using by POCOMAN software.
Adhesive force for IOLs were measured by Tacking Tester (Rhesca Co., Ltd., Tokyo, Japan). Three kinds of IOLs were classified into the three group, A(low adhesive), B(medium) and C(high). 1. The migration area on the collagen membrane was 5.65±4.5% in A group(N=9), 2.83±2.1% in B group(N=8), and 1.41±1.5% in C group(N=7). There were significant difference between A and C group(p<0.05). 2. The mean percentage area of PCO(N=5) was 19.4±16.7% in A, 17.5±8.5% in B, and 5.5±3.8% in C group. There were significant difference between A and C group(p<0.05).
High adhesive IOL material inhibited to HLEC migration and PCO more than low adhesive material. Adhesive force seems to play an important role in preventing PCO.
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