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L. Ugahary, E. Ganteris– Gerritsen, M. Veckeneer, A.C. Cohen, J. Jansen, P.G. H. Mulder, J.C. van Meurs; Topical Ibopamine In The Treatment Of Chronic Ocular Hypotony Due To Vitreoretinal Surgery, Uveitis Or Penetrating Trauma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2610.
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To study whether topical ibopamine effectively increases the intra–ocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis or penetrating trauma
In ten patients with ocular hypotony, a 2% ibopamine or placebo eye drop was administered at 8 AM and 12 AM and frequent applanation tonometry was performed during ten hours on two days two weeks apart
The mean IOP integral after administration of ibopamine was 2.4 mmHg higher (95% CI for median difference in AUC over 480 minutes (p=0.010)) compared to placebo
The results of the study show that a ibopamine 2% eye drop twice a day may increase the IOP for a period of over eight hours in patients with hypotony
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