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A. Pirouzmanesh, S.P. Herretes, O. Suwan–Apichon, J.M. G. Reyes, M. Cano, P. Gehlbach, E. Duh, E. Gurewitsch, A. Behrens; Use of Topical Human Amniotic Fluid in the Treatment of Acute Alkali Burns of the Eye . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2722.
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To evaluate the efficacy of topical human amniotic fluid (HAF) in the treatment of acute alkali burns.
An alkali burn with a drop of 2 µl NaOH 0.15 M was attempted in 30 C57BL/6 mice. Animals were divided into three treatment groups: saline, pre–term HAF, term HAF. Epithelial defect/degree of ocular damage were assessed by blinded observers.
Epithelial defect at day 4 was: 25.13 ± 19.98%; 10.42 ± 5.63% and 7.03 ± 2.45%, respectively (P < .028). Degree of ocular damage at day 14 was: 4.13 ± 2.32; 2.10 ± 1.31, and 2.04 ± 1.37, respectively (P < .036).
Topical HAF was significantly more effective than saline in promoting re–epithelialization and reducing ocular damage in this animal model.
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