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S.E. Pascucci, J. Wittpenn, S. Silverstein, D. Katsev, S. Kaufman; Comparison of Rates of Epithelial Wound Healing With Gatifloxacin and Moxifloxacin Following Penetrating Keratoplasty . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2749.
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To evaluate the effect of gatifloxacin 0.3% (Zymar, Allergan) and moxifloxacin 0.5% (Vigamox, Alcon) ophthalmic solutions on the rate of epithelial wound healing following penetrating keratoplasty.
Randomized, investigator–masked, multi–center clinical trial. Starting on the day of surgery, patients (n= 60) scheduled to undergo corneal transplantation instilled either gatifloxacin or moxifloxacin QID for 2 weeks or until the investigator determined that the epithelium healed. Study visits were scheduled for postoperative days 1, 4, 7, 10, 14, and 21.
In this interim analysis of 27 patients, eyes treated with gatifloxacin had substantially smaller epithelial defects at day 4 than eyes treated with moxifloxacin (mean defect size of 3.7 mm with gatifloxacin vs 7.6 mm with moxifloxacin, P=.339). In addition, 57% of gatifloxacin–treated eyes had completely healed at day 4, compared with 50% of moxifloxacin–treated eyes. By day 7, 100% of gatifloxacin–treated eyes had completed healed, compared with 83% of moxifloxacin–treated eyes. Healing was delayed in 1 moxifloxacin–treated eye until day 21.
The findings of this preliminary analysis suggest that gatifloxacin delays wound healing less than moxifloxacin following penetrating keratoplasty.
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