May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Effect of Intravenous Adenosine Infusion on Ciliary Blood Flow and Aqueous Production in Rabbits
Author Affiliations & Notes
  • J.W. Kiel
    Ophthalmology, Univ of Texas Hlth Sci Ctr, San Antonio, TX
  • Footnotes
    Commercial Relationships  J.W. Kiel, None.
  • Footnotes
    Support  NIH Grant EY09702, RPB Wasserman Award
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 2946. doi:
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      J.W. Kiel; Effect of Intravenous Adenosine Infusion on Ciliary Blood Flow and Aqueous Production in Rabbits . Invest. Ophthalmol. Vis. Sci. 2006;47(13):2946.

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Abstract
 
Purpose:
 

To assess the effects of systemic infusion of adenosine (Ado) on ciliary blood flow and aqueous production.

 
Methods:
 

This study used pentobarbital anesthetized rabbits (n=22, 2.27 ± 0.06 kg) in which the following variables were measured: mean arterial pressure (MAP), intraocular pressure (IOP), and orbital venous pressure (OVP) by direct cannulation, carotid blood flow by transit time ultrasound (BFcar, Transonic Systems TS420), heart rate (HR, digital cardiotachometer), ciliary blood flow by laser Doppler flowmetry (BFcil, Perimed PF 5000, n=7), and aqueous flow by fluorophotometry (Flow, Ocumetrics FM2, n=15). Measurements were made for 90 – 120 min before and during intravenous infusion of Ado (60 µg/min/kg). Results are presented as mean ± SE for the last 60 min of each time period. Responses were evaluated by 2–tailed paired t–tests.

 
Results:
 

 

 
Conclusions:
 

As part of an ongoing investigation of the relationship between ciliary blood flow and aqueous production we sought a drug that stimulates aqueous production. Previous studies reported that topical adenosine agonists increase aqueous production, but the effect on ciliary blood flow was not determined. The present study shows that intravenous adenosine increases aqueous production without a concomitant increase in ciliary blood flow.

 
Keywords: aqueous • blood supply • ciliary body 
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