Purchase this article with an account.
M.A. Ahad, P. Spagnolo, P. Lympany, S. Lightman; Role of CCR–5 Gene Haplotypes in Immune Mediated Posterior Segment Uveitis . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3272.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Immune mediated posterior segment uveitis (PSU) is considered as a complex genetic disorder. Many of the genetic factors likely to influence the clinical course and pattern of PSU are unknown. C–C chemokine receptor 5 (CCR–5) is one of the many inflammatory molecules involved in recruitment of Th1 cells towards site of inflammation. The aim of this study was to see whether polymorphisms in CCR–5 gene can be the predictor of disease predisposition and severity in PSU.
158 British Caucasian patients with PSU were genotyped for nine polymorphisms in CCR–5 gene on chromosome 3. 142 healthy age–matched British subjects served as controls. The genotyping was performed by Single Specific Primer Polymerase Chain Reaction. The genotypic frequencies were compared by Chi square test and haplotypes were constructed using PHASE (version 2) software. Statistical analysis was performed by SPSS (version 12.0).
The frequency of already identified HHC haplotype was significantly lower in patients with PSU (50%) when compared with the controls (64%) p=0.013 OR=0.78; 95% CI: 0.63–0.95. Less number of patients with HHC haplotype (63%) needed systemic steroids as compared to patients not carrying HHC haplotype (82%) (p=0.007)
HHC haplotype of CCR–5 gene can be a protective genotype against immune mediated posterior segment uveitis.
This PDF is available to Subscribers Only