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K.–H. Kim, J. Choi, Y.–H. Kwon, M.S. Kook; Diagnostic Ability of Scanning Laser Polarimetry With Enhanced Corneal Compensation in the Eyes With Typical and Atypical Retardation Pattern . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3352.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the diagnostic ability of the scanning laser polarimetry with enhanced corneal compensation (SLP–ECC) compared with variable corneal compensation (VCC) in the eyes with typical (TRP) and atypical retardation pattern (ARP).
SLP–VCC and ECC were performed on 113 eyes (47 glaucomatous and 66 control) with TRP and 54 eyes (29 glaucomatous and 25 control) with ARP (typical scan score (TSS) < 80). Parameters on SLP printout in each group were compared between SLP–ECC and SLP–VCC. We also assessed the diagnostic ability of SLP–ECC and SLP–VCC in each group based on receiver operating characteristics (ROC) curve.
In both TRP and ARP groups, TSS was higher for ECC than for VCC (p<0.001). In TRP group, TSNIT average and superior average values with SLP–ECC were not different from those acquired with SLP–VCC. In ARP group, TSNIT average and superior average values with SLP–ECC were significantly lower than with SLP–VCC (p<0.001). In both groups, nerve fiber indicator (NFI) was not different between SLP–VCC and SLP–ECC. From ROC curve, in TRP group, sensitivities based on TSNIT average and NFI were similar between SLP–ECC and SLP–VCC. In ARP group, sensitivities based on TSNIT average were 73.3% and 60.0%, respectively for SLP–ECC and SLP–VCC. Sensitivities based on NFI were 80.0% and 66.7%, respectively for SLP–ECC and SLP–VCC (all sensitivities acquired at 80% specificity level). Areas under ROC curve (AUROC) based on SLP–ECC and SLP–VCC images in TRP group were similar for TSNIT average and NFI (p>0.05). AUROC’s in ARP group were greater with SLP–ECC than SLP–VCC (p<0.05; 0.84 and 0.70 for TSNIT average, 0.90 vs 0.83 for NFI).
SLP–ECC has a potential advantage over SLP–VCC in the acquisition of typical polarimetric images and may improve diagnostic ability in eyes showing atypical retardation pattern.
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