May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Reproducibility and Test–retest Variability of Stratus OCT Peripapillary RNFL Measurements in Glaucomatous Eyes
Author Affiliations & Notes
  • D.L. Budenz
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • M.–J. Fredette
    Ophthalmology, Lasval University, Quebec City, PQ, Canada
  • W.J. Feuer
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • D.R. Anderson
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL
  • Footnotes
    Commercial Relationships  D.L. Budenz, Carl Zeiss Meditec, F; Carl Zeiss Meditec, R; M. Fredette, Carl Zeiss Meditec, F; Carl Zeiss Meditec, C; W.J. Feuer, Carl Zeiss Meditec, F; D.R. Anderson, Carl Zeiss Meditec, F.
  • Footnotes
    Support  NEI grant EY014801; Research to Prevent Blindness; Carl Zeiss Meditec
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 3368. doi:
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    • Get Citation

      D.L. Budenz, M.–J. Fredette, W.J. Feuer, D.R. Anderson; Reproducibility and Test–retest Variability of Stratus OCT Peripapillary RNFL Measurements in Glaucomatous Eyes . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3368.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To determine the reproducibility and test–retestvariability of STRATUS OCT peripapillary RNFL scans in glaucomapatients.

 
Methods:
 

51 stable glaucoma subjects were measured using theFast Peripapillary RNFL scan of the STRATUS OCT on 5 differentdays in a 2 month period. The same OCT unit was used by thesame operator for all scans. Intraclass correlation coefficient(ICC), coefficient of variation (COV), and test–retestvariability (defined as twice the standard deviation of the5 repeated measures) were calculated for the mean RNFL thickness,quadrant, and clock hours.

 
Results:
 

ICC for mean RNFL was 0.96. ICCs for temporal, superior,nasal, and inferior quadrants were 0.92, 0.91, 0.80, and 0.95respectively. COV was 4.9% for mean RNFL thickness and 9.3%,9.4%, 11.6%, and 8.3% for temporal, superior, nasal, and inferiorquadrants respectively. Test–retest variability was 7.1microns for mean RNFL and 10.0, 14.7, 12.9, and 12.2 micronsfor the temporal, superior, nasal, and inferior quadrants respectively.Similar low variability was found in clock hour measurements(Figure 1). There was little variability in RNFL measurementsthroughout the range of thickness values obtained (Figure 2).

 
Conclusions:
 

Because the Fast RNFL scanning program of the STRATUSOCT has excellent reproducibility, we expect measurements ofperipapillary RNFL in sectors or globally may prove useful inmonitoring glaucomatous progression.  

 

 
Keywords: imaging/image analysis: clinical 
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