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D.L. Budenz, M.–J. Fredette, W.J. Feuer, D.R. Anderson; Reproducibility and Test–retest Variability of Stratus OCT Peripapillary RNFL Measurements in Glaucomatous Eyes . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3368.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the reproducibility and test–retestvariability of STRATUS OCT peripapillary RNFL scans in glaucomapatients.
51 stable glaucoma subjects were measured using theFast Peripapillary RNFL scan of the STRATUS OCT on 5 differentdays in a 2 month period. The same OCT unit was used by thesame operator for all scans. Intraclass correlation coefficient(ICC), coefficient of variation (COV), and test–retestvariability (defined as twice the standard deviation of the5 repeated measures) were calculated for the mean RNFL thickness,quadrant, and clock hours.
ICC for mean RNFL was 0.96. ICCs for temporal, superior,nasal, and inferior quadrants were 0.92, 0.91, 0.80, and 0.95respectively. COV was 4.9% for mean RNFL thickness and 9.3%,9.4%, 11.6%, and 8.3% for temporal, superior, nasal, and inferiorquadrants respectively. Test–retest variability was 7.1microns for mean RNFL and 10.0, 14.7, 12.9, and 12.2 micronsfor the temporal, superior, nasal, and inferior quadrants respectively.Similar low variability was found in clock hour measurements(Figure 1). There was little variability in RNFL measurementsthroughout the range of thickness values obtained (Figure 2).
Because the Fast RNFL scanning program of the STRATUSOCT has excellent reproducibility, we expect measurements ofperipapillary RNFL in sectors or globally may prove useful inmonitoring glaucomatous progression.
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