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F. Djafari, J. Lachaine, P. Harasymowycz, D. Desjardins, M.R. Lesk; Study of the Determinants of Glaucoma Treatment Compliance . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3387.
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To estimate patients’ compliance with their glaucoma medications and identify potential determinants of non–compliance to glaucoma treatment.
200 patients with open angle glaucoma or ocular hypertension were interviewed about their glaucoma condition and treatment. After the visit, their ophthalmologist was asked to complete a brief assessment form. Data on drug utilization and medical services were extracted from the provincial drug program database.Patients were considered as compliant if they had received at least 75% of the quantity of medication required according to the recommended dosage for each medication
Data were available for 197 patients. 63.5% were female and the mean age (± standard deviation, SD) was 75.3 ± 8.6 years. The mean number of years of glaucoma treatment was 10.5 ± 9.1 years and the proportion of patients with treatment changes in previous year was 24.4%. Self–reported treatment compliance was 88.3%. According to physicians, 74.6% of patients were at least 75 %compliant. Based on utilization in drug database the proportion of patients who were at least 75% compliant to treatment was 65.0%. Among patients considered by physicians as non–compliant 54% (27/50) were non– compliant and among patients predicted as compliant 71.4% (105/147) were compliant (p=0.001, Chi–square). There was no significant difference in compliance according to age, gender, education and income. Hypertension (p=0.029), diabetes (p=0.016), ethnicity (p=0.042) and knowledge about glaucoma (p=0.000) were associated with compliance.
The estimation of glaucoma treatment compliance based on utilization in a drug database is higher than compliance reported in previous studies. Physicians are able to predict with some significance which patients are compliant and non–compliant. Ethnicity, hypertension, diabetes and knowledge about glaucoma are significantly associated with compliance.
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