Purchase this article with an account.
A.M. Wagle, T.P. Yap, B.C. Tai, K.G. Au Eong, C.C. Yip; Efficacy of a Single Drop versus 3–Drop Regime Using 1% Tropicamide for Mydriasis in Patients With Darkly Pigmented Irides – A Randomized Controlled Trial . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3491.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the efficacy of a single drop versus a 3–drop regime using 1% tropicamide for mydriasis in patients with darkly pigmented irides.
A prospective randomized, single masked clinical trial involving 30 patients (60 eyes) with darkly pigmented irides. One eye of each patient was randomly assigned to receive a single drop of 1% tropicamide (Regime A) while the other eye received one drop of 1% tropicamide thrice at 5–minute intervals (Regime B). A masked observer measured the pupil size in both eyes at 5–minute intervals for 45 minutes using a reference pupil chart.
The median age of the participants was 53 years (range, 20 – 80) with 47% males and 53% females. The ethnic distribution was 53% Chinese, 27% Indian and 20% Malay. Six patients were diabetic. The pupil size at 45 minutes (PS–45) and the rate of mydriasis (RM in mm/min) were not significantly different between the 2 regimes (p = 0.081 and p = 0.056 respectively). The efficacy of the regimes, in terms of PS–45 and RM, was not affected by ethnicity (p = 0.091 and p = 0.434 respectively), the presence of diabetes mellitus (p = 0.312 and p = 0.219 respectively) or age (p = 0.211 and p = 0.263 respectively).
A single–drop of 1% tropicamide is as efficacious as a 3–drop regime in dilating pupils of darkly pigmented irides. The efficacy of the regimes is not influenced by ethnicity, the presence of diabetes mellitus or age.
This PDF is available to Subscribers Only