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S.S. Patel, D. Meisler, A. Roth, M. Telisman, B. Jeng, E. Rockwood; Indications and Outcomes of Repeat Penetrating Keratoplasties at the Cole Eye Institute . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3598.
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To evaluate the indications for and outcomes of repeat penetrating keratoplasties at the Cole Eye Institute over a 9–year period.
A retrospective chart review was performed of all patients who underwent repeat penetrating keratoplasties between January 1, 1995 and December 31, 2003.
During the study period, 73 repeat penetrating keratoplasties were performed on 58 eyes, including 19 patients who had had a previous corneal graft at another hospital. The most common indications for the initial penetrating keratoplasties were pseudophakic bullous keratopathy (42.1%), aphakic bullous keratopathy (13.2%), Fuchs’ endothelial dystrophy (11.8%), interstitial keratitis (10.5%), keratoconus (7.9%), and corneal ulceration (7.6%). Average duration of graft survival before the first repeat penetrating keratoplasty was 72.7 months, with the shortest duration found in eyes grafted for Fuchs’ endothelial dystrophy (21.3 months) and the longest duration in eyes grafted for keratoconus (102.5 months). As the number of grafts performed in an eye increased, the difference in duration of graft survival was not statistically significant, but there was a trend towards decreasing duration of graft survival. Average graft survival after the first, second, and third re–grafts were 65.5 months, 54.3 months, and 48.2 months, respectively. In addition, the LogMAR best corrected visual acuity increased significantly after the first regraft as compared to after the initial graft (1.28 versus 0.931, p<0.05).
With an increasing number of re–grafts in an eye, there is a trend towards shorter duration of graft survival. In addition, there is a statistically significant decrease in best corrected visual acuity after a re–graft as compared to after an initial graft.
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