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P.T. Chang, P.W. Park, D.L. Budenz, N. Sekhon, D.R. Anderson; Effect of Intraocular Pressure Lowering on Optical Coherence Tomography Measurement of Retinal Nerve Fiber Layer Thickness . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3649.
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© ARVO (1962-2015); The Authors (2016-present)
To study the effect of intraocular pressure (IOP) lowering on the peripapillary retinal nerve fiber layer (PRNFL) thickness as determined by the newest generation of optical coherence tomography (OCT; Stratus OCT, Carl Zeiss, Inc.)
OCT was performed prior to intervention to lower IOP (0 to 38 days before; mean ± standard deviation [SD], 9.8 ± 9.3 days) and after the intervention (32 to 74 days; 46.8 ± 11.2 days) to measure PRNFL thickness. The intervention involved trabeculectomy with antimetabolite, Baerveldt aqueous shunt implantation, or medical treatment.
IOP decreased from 31.5 ± 8.2 mm Hg to 18.8 ± 9.4 mm Hg (mean ± SD) with the intervention. There was no significant change in the overall mean PRNFL thickness associated with the lowering of IOP (p = 0.65). Quadrant analysis did not show a significant change in PRNFL thickness of any of the four quadrants (p ≥ 0.30). No significant correlation was found between extent of IOP reduction and any of the changes in OCT parameters or % changes in OCT parameters with or without adjusting for pre–operative OCT measurements (p–values ranged from 0.33 to 0.99).
No significant change in PRNFL thickness was associated with the lowering of IOP via medical or surgical therapy.
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