May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Resonance Raman Spectroscopic Measurement of Macular Carotenoids in Normal and Myopic Eyes of Young European Subjects
Author Affiliations & Notes
  • C. Brue
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • F. Luciani
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • S. Celani
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • M. Manenti
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • P. Neri
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • G. Finicelli
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • C. Mariotti
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • A. Giovannini
    Clinica Oculistica, Università Politecnica delle Marche, Ancona, Italy
  • Footnotes
    Commercial Relationships  C. Brue, None; F. Luciani, None; S. Celani, None; M. Manenti, None; P. Neri, None; G. Finicelli, None; C. Mariotti, None; A. Giovannini, None.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 3796. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      C. Brue, F. Luciani, S. Celani, M. Manenti, P. Neri, G. Finicelli, C. Mariotti, A. Giovannini; Resonance Raman Spectroscopic Measurement of Macular Carotenoids in Normal and Myopic Eyes of Young European Subjects . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3796.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Light–adsorbing macular carotenoids (MCs), i.e. lutein and zeaxanthin, are efficient free radical scavengers in the human retina and might play a role in the pathogenesis of major myopia–related diseases, such as choroidal neovascularisation. The present study aimed at verifying whether MCs levels correlate with the myopia grade.

Methods: : Sixty–three European 20–31 years old (mean age 26.3 years) healthy subjects were divided in four matched groups: i) control (negative for myopia, n=25); and ii) mild (< 3 D, n=12), iii) medium (3–6 D, n=14) and, iv) high (> 6 D, n=12) myopia. The levels of MCs were measured by a resonance Raman spectroscope in all of the subjects. Both the eyes of each subject were monitored and triplicate measurements were performed at each time. Moreover, pupil dilatation, instrument self–adjustment and appropriate eyeglasses correction were used.

Results: : MCs levels, measured as Raman counts (SD), were 2425 (279), 2348 (195), 1928 (410) and 1921 (690) in the control, mild, medium and high myopia groups, respectively. The difference among the groups was statistically significant (p < 0.01). At the pairwise comparisons, the difference between the control and high myopia groups was also statistically significant (p < 0.05). Interestingly, a significant negative correlation was found between the MCs levels and the myopia grade (Spearman rho 0.50, p < 0.01).

Conclusions: : A role for MCs in the pathogenesis and grade of myopia is proposed herein and future investigations are warranted to further clarify these aspects and to test their possible clinical use in the treatment of this pathology.

Keywords: myopia • carotenoids/carotenoid binding proteins • nutritional factors 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×