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E. Prandovszky, V. Tiwari, D. Shukla, T. Valyi–Nagy; Expression of Herpesvirus Entry Mediator (HVEM) in the Retina and Trigeminal Ganglia . Invest. Ophthalmol. Vis. Sci. 2006;47(13):3819.
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Herpesvirus entry mediator (HVEM) is a member of the tumor necrosis factor receptor family. HVEM is one of the known entry receptors for herpes simplex virus, an important pathogen targeting the retina and trigeminal ganglia. The expression pattern of HVEM in the retina and in the trigeminal ganglia is essentially unknown. The purpose of this study was to determine whether HVEM is expressed in the retina and trigeminal ganglia.
HVEM expression in the retina and trigeminal ganglia of adult BALB/c mice was determined by immunohistochemistry using a polyclonal rabbit anti–HVEM antibody.
In the retina, strong HVEM expression was detected in optic nerve fibers, in ganglion cells, in the inner plexiform layer and in pigmented epithelial cells. Weaker HVEM expression was noted in the inner limiting membrane, in the outer plexiform layer and in the processes of rods and cones. Focal HVEM staining was detected in the inner nuclear layer. The outer nuclear layer and the outer limiting membrane were negative for HVEM expression. In the trigeminal ganglia, neurons and non–neuronal cells demonstrated variable HVEM expression ranging from negative staining of some neurons and non–neuronal cells and strong staining of others.
These findings indicate that HVEM is expressed by some cells in the retina and trigeminal ganglia and suggest that HVEM may serve as an entry receptor for HSV during HSV infections of these tissues. As the expression and distribution of entry receptors is thought to be an important determinant of HSV tissue tropism and cell–to–cell spread, these findings may help to develop novel preventive and therapeutic strategies against HSV–induced ocular and nervous system diseases.
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