May 2006
Volume 47, Issue 13
ARVO Annual Meeting Abstract  |   May 2006
Reproducibility Of Anterior Chamber Angle Measurements Obtained With Anterior Segment Optical Coherence Tomography
Author Affiliations & Notes
  • S. Radhakrishnan
    Ophthalmology, Cole Eye Institute, Cleveland, OH
  • J. See
    Ophthalmology, NUH, Singapore, Singapore
  • P. Chew
    Ophthalmology, NUH, Singapore, Singapore
  • W. Nolan
    Ophthalmology, NUH, Singapore, Singapore
  • Z. Ce
    Ophthalmology, NUS, Singapore, Singapore
  • D.S. Friedman
    Ophthalmology, Wilmer Eye Institute, Baltimore, MD
  • T. Aung
    Ophthalmology, NUS, SNEC, Singapore, Singapore
  • S.D. Smith
    Ophthalmology, Cole Eye Institute, Cleveland, OH
  • Footnotes
    Commercial Relationships  S. Radhakrishnan, Carl Zeiss Meditec, Inc, C; J. See, None; P. Chew, None; W. Nolan, None; Z. Ce, None; D.S. Friedman, None; T. Aung, None; S.D. Smith, Carl Zeiss Meditec, Inc, F.
  • Footnotes
    Support  Carl Zeiss Meditec, Inc
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4015. doi:
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      S. Radhakrishnan, J. See, P. Chew, W. Nolan, Z. Ce, D.S. Friedman, T. Aung, S.D. Smith; Reproducibility Of Anterior Chamber Angle Measurements Obtained With Anterior Segment Optical Coherence Tomography . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4015.

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      © ARVO (1962-2015); The Authors (2016-present)

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To evaluate the reproducibility of anterior chamber (AC) angle measurements obtained using anterior segment optical coherence tomography (AS–OCT).


Glaucoma suspects and patients with glaucoma, ocular hypertension or anatomically narrow angles were recruited from the glaucoma service at the National University Hospital, Singapore. All subjects underwent imaging of the nasal, temporal and inferior AC angles with an AS–OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA) under dark and light conditions. A single observer acquired two sets of images followed by a third set of images acquired by a second observer. The duration between sessions was 10 minutes. Images were measured by an independent third observer using custom software (Mathworks, Natick, MA) to determine the AC depth (ACD), angle opening distance at 500µm (AOD500), angle recess area at 500µm (ARA500) and trabecular–iris space area at 500µm (TISA500). Analysis of variance was used to calculate the intraclass correlation coefficient (ICC) as a measure of intraobserver and interobserver reproducibility.


Twenty eyes of 20 patients were analyzed. AC depth measurement demonstrated excellent reproducibility (ICC 0.93–1.00) in both dark and light conditions. For the nasal and temporal quadrants, all AC angle parameters demonstrated good to excellent intraobserver and interobserver reproducibility. In the inferior quadrant, reproducibility was lower and varied from poor to good. Table1 . ICCs for AC angle parameters  


AS–OCT is a promising imaging device that allows quantitative assessment of the AC angle. The reproducibility of AC angle measurements was good to excellent for the nasal and temporal quadrants. The lower reproducibility of measurements in the inferior quadrant may be unique to this prototype due to difficulty in acquiring high–quality images of the inferior angle.

Keywords: anterior segment • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • imaging/image analysis: clinical 

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