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J.R. Trevithick, T.M. Dzialoszynski, M.M. Collins, J. Foster, M. Hirst, S.E. Sanford, S.E. Sanford; Luteolin or Isoquercetin: Antioxidant Potency and Dietary Effects on Diabetic Rats . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4122.
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Luteolin or isoquercetin was used (a) in vitro as an antioxidant and (b) in vivo to determine whether it could reduce damage in model diabetic cataract.
For (a), the Inhibitory Concentration for 50 % inhibition (IC50 )of our in vitro antioxidant assay. For (b) cataract grades of streptozotocin diabetic rats fed 0.5% luteolin or isoquercetin were followed every 2 wk for 9 weeks.
Luteolin or isoquercetin in vitro was an antioxidant when challenged with peroxide. In vivo feeding luteolin or isoquercetin resulted in similar growth and body condition for diabetic rats, and luteolin showed higher cataract grades at 7 weeks than untreated diabetic rats. After 5 and 9 weeks, diabetic rats supplemented with isoquercetin had lower cataract grade, which at 9 weeks only showed a trend to significance (p<0.075). Final serum glucose levels at 9 weeks were not significantly different, but glycohemoglobin A1 levels were significantly lower (60.0 %, p<0.05) in luteolin–fed diabetic rats.
Luteolin or isoquercetin both are potent antioxidants. Luteolin appears in vivo to have a transient cataract–potentiating effect, but also significantly reduces glycation of proteins, and either luteolin or quercetin decrease (but not significantly) the plasma glucose concentration.
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