Purchase this article with an account.
W.G. Christen, R.J. Glynn, E.Y. Chew, J.E. Buring; Age–Related Cataract in a Randomized Trial of Vitamin E in Women . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4137.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To examine incidence of visually–significant age–related cataract and extraction in a randomized trial of vitamin E.
The Women's Health Study was a randomized, double–blind, placebo–controlled trial of vitamin E (600 IU of natural–source vitamin E taken on alternate days) and low–dose aspirin (50 mg on alternate days) in the prevention of cancer and cardiovascular disease among 39,876 women aged 45 years or older. A total of 37,688 participants did not report cataract at baseline and were included in this analysis. Age–related cataract was defined as an incident, age–related lens opacity, responsible for a reduction in best–corrected visual acuity to 20/30 or worse, based on self–report confirmed by medical record review.
During an average of 10 years of treatment and follow–up, a total of 2,378 cataracts and 1,554 cataract extractions were confirmed. There were 1,160 cataracts in the vitamin E group and 1,218 cataracts in the placebo group (relative risk [RR], 0.96; 95% confidence interval [CI], 0.88–1.04). In analyses of cataract subtypes, there were no significant effects of vitamin E on incidence of nuclear (RR, 0.94; CI, 0.87–1.03), cortical (RR, 0.93; CI, 0.82–1.06), or posterior subcapsular cataract (RR, 1.00; CI, 0.87–1.16). For cataract extraction, there were 775 in the vitamin E group and 779 in the placebo group (RR, 1.01; CI, 0.91–1.11). In analyses of subtypes, there were no significant effects of vitamin E on extraction of nuclear (RR, 1.00; CI, 0.90–1.11), cortical (RR, 0.92; CI, 0.78–1.08), or posterior subcapsular cataract (RR, 1.08; CI, 0.92–1.27). For both cataract and cataract extraction, RRs did not vary significantly according to known risk factors for cataract including age, smoking, body mass index, and diabetes.
These randomized trial data from a very large cohort of women indicate that ten years of alternate–day supplementation with 600 IU of natural–source vitamin E has no material beneficial or harmful effect on age–related cataract or cataract extraction.
This PDF is available to Subscribers Only