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I.J. Immonen, S. Seitsonen, J. Holopainen, I. Järvelä, P. Ranta, Sr., P. Ranta, Sr., 1A, P. Tommila; The Effect of Cfh Y402h Polymorphism on Recent Exudative AMD Lesion Parameters . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4340.
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To evaluate the impact of CFH Y402H polymorphism on clinical parameters in recent exudative AMD lesions.
We analyzed the clinical data and fluorescein angiograms of 165 unselected patients attending the retina clinic at our institution for recent exudative AMD.The presence and area of various lesion parameters were recorded from the digital (Topcon or Heidelberg) angiograms.
Mean lesion size (classic+occultcnv+serous PED, if present) was 11.0 mm2 in patients, homozygous for the CHF polymorphism (CC), 8.8 mm2 in heterozygous patients (CT) and 8.5 mm2 in those with the normal genotype (TT)(ns). The areas of classic and occult cnv together but without serous PED area were 8.7, 6.8 and 5.6 mm2, respectively(ns). There was a trend for the CC patients to have more frequently the minimally classic, and less frequently the predomintly classic lesion composition than the CT or TT subjects..
We observed a trend for the lesions to be larger and more frequently minimally classic in patients homozygous for the CHF Y402H polymorphism, but the obsevations did not reach statistical significance.
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