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M.C. Pache, A. Planert, T. Kube, J. Funk; Comparison of Central Corneal Thickness Measurements by Stratus–OCT, Ultrasound Pachymetry and Orbscan II in Normal and Glaucoma Eyes . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4454.
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© ARVO (1962-2015); The Authors (2016-present)
We evaluated the capability of the Stratus–OCT to assess central corneal thickness (CCT) in normals and glaucoma patients and compared the method with ultrasound pachymetry (UP) and Orbscan II.
We prospectively assessed CCT in 200 eyes of 100 subjects (50 normals, 35 POAG, 9 NTG, 6 OHT patients) in randomized order. We compared the results of 3 measurements by OCT and Orbscan II and 5 measurements by UP with respect to mean value, SD, eye symmetry, reproducibility, and level of agreement between the 3 methods.
Mean CCT values where highest by UP (555±37 µm for right eyes, 560±37 µm for left eyes), followed by OCT (549±36 µm for right eyes, 550±37 µm for left eyes) and Orbscan II (536±41 µm for right eyes, 537±41 µm for left eyes). The difference between right and left eyes was significant for UP. Intraclass correlation coefficient Kappa was 0.99 for UP and OCT and 0.98 for Orbscan II. Bland–Altman analysis demonstrated a higher level of agreement between OCT and UP than between Orbscan II and OCT and Orbscan II and UP. Patients with NTG showed the lowest, patients with OHT the highest CCT.
The Stratus–OCT allows highly reproducible non–contact assessment of CCT with a high level of agreement with UP. The symmetry between both eyes was even higher with this method. In agreement with previous studies, NTG patients showed a lower, OHT patients a higher CCT than normals.
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