Purchase this article with an account.
M. Uchida, K. Mori, Y. Ikeda, Y. Hozono, T. Ikushima, H. Mizuno, M. Ikushima, S. Kinoshita; Influence Of Latanoprost Instillation On The Central Corneal Thickness . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4456.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
latanoprost is one of the prostaglandin derivatives which activate matrix metalloproteinases, decreasing collagen fiber bundles among ciliary muscle. Similar effects may cause the decrease of central corneal thickness (CCT). In this study, we investigated the influence of latanoprost instillation on CCT with glaucoma patients in a short term observation period.
Subjects and Methods: :
Twenty one eyes from 21 glaucoma patients (6 female, 15 male) were retrospectively examined (mean age 57±17 years old; mean observation period 7.8±7.8 month), who had newly received latanoprost and could be followed up more than 1 month in Kyoto Prefectural University of Medicine Hospital from December 2001 to November 2005. For the further analysis, we chose the data form right eyes in case both eyes data were available. Intraocular pressure (IOP) and CCT were measured before and 1, 3, 6, 12 months after the instillation of latanoprost, using Goldmann applanation tonometer and IOPac (Heidelberg Engineering) or Pentacam (Oculus), respectively. For the statistical data analysis, paired t tests were used.
IOP at baseline, 1, 3, 6 and 12 month after starting latanoprost instillation were 16.8±4.5, 10.9±3.1, 11.8±4.2, 10.2±3.7, 13.8±2.2 mmHg, respectively. IOP at every observation period was significantly decreased compared to the baseline IOP. As for CCT, there was no significant difference in all observation period compared to baseline CCT (baseline, 1, 3, 6 and 12 month after latanoprost was 552.4±43.2, 525.6±41, 555.7±41.2, 543.2±53.2, 567.2±33.1µm, respectively.)
There was no significant decrease in CCT after latanoprost instillation during 1 year observation periods.
This PDF is available to Subscribers Only