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E. Zamir, A. Traill, A. Hall, R. Stawell; Macular Changes In Acute Anterior Uveitis: An Optical Coherence Tomography Study . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4503.
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© ARVO (1962-2015); The Authors (2016-present)
To elucidate whether sub–clinical macular thickening is a feature of typical acute anterior uveitis (AAU).
Observational, prospective case series. Fifteen consecutive cases of typical, acute, unilateral, non–granulomatous AAU with best corrected visual acuity of 6/9 or worse were compared to twelve age matched controls. Optical coherence tomography (OCT) was performed within 7 days of onset. Macular thickness was compared between the affected and healthy eye of each patient.
Fourteen out of 15 AAU patients were HLA B27–positive. Thirteen patients demonstrated sub–clinical macular thickening by OCT. Mean macular thickness asymmetry was 11.1% and 1.6% in patients and controls, respectively (p<0.0001). Mean macular volume asymmetry was 10% and 1% in patients and controls, respectively (p<0.0001). Thickness asymmetry as measured by OCT persisted beyond subjective and functional recovery, but largely resolved within 6 months.
Transient, diffuse, sub–clinical macular thickening is a previously–unrecognised but frequent phenomenon in acute anterior uveitis. It may play a role in the pathogenesis of transient visual impairment in such cases.
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