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A.C. Crichton, J.R. Hernandez, J. Gohill; Central Corneal Thickness Changes in Patients With Chronic Unilateral Uveitis . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4509.
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To compare the central corneal thickness (CCT) between the two eyes in patients with unilateral chronic uveitis.
A retrospective case review of 20 eyes with active or recurrent unilateral uveitis lasting longer than 3 months was done. Patients with corneal pathology, trauma and contact lens wearers were excluded. CCT measurements were obtained for each eye. An additional CCT measurement was performed to look for a possible changing pattern. The CCT measurements were examined to see whether there was a relationship between the length of uveitic state, number of glaucoma and steroid drops, and type of ocular surgeries.
There was a thinner CCT in the uveitic eyes in 19/20 (mean 532.3µm SD:+/–40.5) compared to the non–uveitic eyes (mean 559.9µm SD:+/–27.0). The mean difference between eyes was 27.6µm SD:+/–27.5 (p<0.001). An additional CCT measurement was obtained in 18/20 and it was not significantly different. The average length of uveitic state was 10.4 years (range 1–22). All patients were unable to discontinue steroid use since initial diagnosis. The mean initial intraocular pressure (IOP) of the uveitic eyes was 25.8 mm Hg with an average number of glaucoma drops of 3.2. The mean IOP at the moment of the additional CCT measurement was 12.5 mm Hg, with an average number of drops of 0.99. Trabeculectomy was performed in 13/20 and a glaucoma drainage device was inserted in 4/20. 4/20 patients did not require surgery. There was a direct relationship between length of uveitic state and CCT difference between the two eyes using linear regression. There was no correlation of CCT to drops or surgeries.
There was a significantly thinner central corneal measurement in eyes with unilateral chronic uveitis compared to the contralateral normal eyes. CCT measurements were correlated to length of uveitic state. Steroid use maybe a factor, but a prospective study isolating the variables is needed.
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