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J.A. Mackiewicz, W. Hiebl, H. Meinert, B. Muhling, K. Maaijwee, C. Luke, N. Kociok, Z. Zagórski, B. Kirchhof, A.M. Joussen; Retinal Tolerance of Heavy Silicone Oil Using Perfluorobutylpentane Dependent of Viscosity and Density . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4679.
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Heavy silicone oils are currently under investigation as a permanent tamponade in eye with inferior PVR. Here, we investigated Densiron 68 ® and two new heavy silicone oils on the basis of perfluorobutylpentane (F4H5) of variable viscosity and density with respect to their long–term tolerability in a rabbit model
After vitrectomy and fluid–air exchange, the left eye of each 5 rabbits in each group was filled with either HSO 1500 (Densiron 68 ®), Perfluorobutylpentane and HSO 3000 or HSO 5000 mPas viscosity. Densiron 68 ® (Fluoron GmbH, Germany) is a mixture of 30.5 weight–% F6H8 und 69.5 weight–% silicone oil 5000. Due to the higher solubility of F4H5 in comparison with F6H8, we used F4H5 to generate highly viscous heavy silicone oils. To create the high viscosity required, highly purified F4H5 was added to silicone oils (pharmaceutical grade) of 60,000 mPas and 100,000 mPas viscosity. In addition, we investigated the biocompatibility of pure F4H5 as tamponading agent. Siluron 1000 and 5000 (Fluoron GmbH, Germany) served as a control as well as silicone oil of 3000 mPas generated form a combination of both. Detailed clinical investigation, ERG testing and histological evaluation was performed throughout a 3 months follow–up.
All heavy silicone oils tested (Densiron 68 ®, HSO 3000 und 5000) as well as the three controls (silicone oil of 1000, 3000, and 5000 mPas) were well tolerated over 3 months in a rabbit model. There was no emulsification nor inflammatory reaction or cataract formation in either of the heavy silicone oils or the controls. ERG–testing demonstrated no functional alterations. Histologically, the retina was unaffected. If pure F4H5 was investigated, in 50% of the eyes some emulsification but no inflammatory reaction nor histological damage was observed within three months.
All silicone oils and the heavy silicone oils tested as well as pure F4H5 were biocompatible in long–term tamponade in the rabbit eye. Heavy silicone oils on the basis of F4H5 combine the advantages of an inferior permanent tamponade with an adjustable higher density.
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