May 2006
Volume 47, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2006
Ultrasound Biomicroscopy for Estimation of Tumor Thickness for Conjunctival Melanoma
Author Affiliations & Notes
  • V.H. Ho
    University of Texas MD Anderson Cancer Center, Houston, TX
    Ophthalmology,
  • T.C. Prager
    Ophthalmology, University of Texas Health Science Center, Houston, TX
  • H. Diwan
    University of Texas MD Anderson Cancer Center, Houston, TX
    Pathology,
  • B. Esmaeli
    University of Texas MD Anderson Cancer Center, Houston, TX
    Ophthalmology,
  • Footnotes
    Commercial Relationships  V.H. Ho, None; T.C. Prager, None; H. Diwan, None; B. Esmaeli, None.
  • Footnotes
    Support  Research to prevent blindness
Investigative Ophthalmology & Visual Science May 2006, Vol.47, 4701. doi:
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      V.H. Ho, T.C. Prager, H. Diwan, B. Esmaeli; Ultrasound Biomicroscopy for Estimation of Tumor Thickness for Conjunctival Melanoma . Invest. Ophthalmol. Vis. Sci. 2006;47(13):4701.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To assess the feasibility of using high–frequency ultrasound biomicroscopy (UBM) in estimating thickness of conjunctival melanomas preoperatively.

Methods: : Three patients underwent UBM prior to excision of conjunctival melanoma between February 2003 and June 2006. UBM using a standoff immersion shell was performed under topical anesthesia. In each patient, the thickness of the surgical specimen was also determined using Breslow’s method.

Results: : Patient 1 had an estimated thickness of 1.99 mm by UBM, versus a Breslow thickness measurement of 1.5 mm based on the surgical specimen. Patient 2 had a UBM thickness measurement of 2.4mm and a Breslow thickness of 2.23 mm based on the surgical specimen. Patient 3 had a UBM thickness measurement of 2.4mm but the Breslow thickness estimated based on the surgical specimen was 5.3 mm.

Conclusions: : The use of high–frequency ultrasound biomicroscopy is feasible for estimation of tumor thickness for conjunctival melanomas. UBM may serve as an additional diagnostic tool for estimating tumor thickness prior to surgical resection of conjunctival melanoma. Larger studies would be needed to correlate the UBM thickness measurements with Breslow thickness and to determine the accuracy of UBM for this purpose.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • conjunctiva • melanoma 
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